Caenorhabditis elegansGenAge entry for tatn-1 (Caenorhabditis elegans)

Gene information (ID: 2008)

Symbol
tatn-1
Name
Tyrosine AminoTraNsferase
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Worms with tatn-1 mutations (baf1, partial loss-of-function), impairing tyrosine aminotransferase activity, show elevated levels of tyrosine, are prone to arresting development in dauer stage, and display increased longevity compared to wild type N2 controls (mean lifespan ~10% longer). Similar effects were observed for worms which have tatn-1 inhibited by RNA interference (~9%). Additionally, tatn-1 mutations or RNA interference also extend the lifespan of the eak7 (by ~12%) and daf-2 (by ~21%) long-lived mutants. The longevity extension effect of tatn-1 is dependent on aak-2 and daf-16 independent.
% change in avg or median lifespan
Mean lifespan is approximately 10% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    tat
    Drosophila melanogaster
    CG1461
    Homo sapiens
    TAT
    Mus musculus
    Tat
    Rattus norvegicus
    Tat
    Saccharomyces cerevisiae
    BNA3

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (181574)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar