Caenorhabditis elegansGenAge entry for sptl-1 (Caenorhabditis elegans)

Gene information (ID: 1920)

Symbol
sptl-1
Name
Serine Palmitoyl Transferase famiLy
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
RNA interference of SPTL-1 (C23H3.4), serine palmitoyl transferase homolog, results in both mean and maximum lifespan extension.
% change in max lifespan
Maximum lifespan is 20% higher.
% change in avg or median lifespan
Mean lifespan is 33% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    sptlc1
    Drosophila melanogaster
    Spt-I
    Homo sapiens
    SPTLC1
    Mus musculus
    Sptlc1
    Rattus norvegicus
    Sptlc1
    Saccharomyces cerevisiae
    LCB1
    Schizosaccharomyces pombe
    lcb1

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (173389)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar