GenAge entry for spr-3 (Caenorhabditis elegans)
Gene information (ID: 1896)
- Symbol
- spr-3
- Name
- Suppressor of presenilin protein 3
- Organism
- Caenorhabditis elegans (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Deletion or RNA interference of spr-3 results in a short lifespan phenotype for worms. Contrarly, worm mutants with a gain-of-function mutation of spr-3 (by108) display resistance to environmental stress and an increased lifespan (by 26%) when compared with wild-type nematodes. This mutation is dependent on daf-16 and glp-1.
- % change in avg or median lifespan
- Mean lifespan is 26% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
Homologs in other organisms
No homologs found
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (180722)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar