Caenorhabditis elegansGenAge entry for skr-2 (Caenorhabditis elegans)

Gene information (ID: 614)

Symbol
skr-2
Name
SKp1 Related (ubiquitin ligase complex component)
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
SKp1 Related (ubiquitin ligase complex component)

Potential relevance to longevity and/or ageing

Observations
RNA interference in adulthood of skr-1 and skr-2 shortened the extended lifespan of daf-2(mu150) mutants by up to 44%. No effect in the lifespan of wild-type worms or in the extended lifespans of glp-1(e2141ts) or eat-2(ad1116) mutants was observed.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    skp1
    Drosophila melanogaster
    SkpB
    Drosophila melanogaster
    SkpF
    Drosophila melanogaster
    SkpE
    Drosophila melanogaster
    SkpC
    Drosophila melanogaster
    SkpA
    Drosophila melanogaster
    SkpD
    Homo sapiens
    0
    Homo sapiens
    SKP1
    Mus musculus
    Skp1a
    Rattus norvegicus
    Skp1
    Saccharomyces cerevisiae
    SKP1

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (172773)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar