- Symbol
- rpc-1
- Name
- RNA Polymerase, Class III
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Downregulating rpc-1 (a subunit of Pol III) in worms increased mean lifespan by 36% at 20 degrees celcius. Lifespan was also increased at 25 degrees celcius, though less markedly. Gut specific downregulation also increased lifespan.
- % change in avg or median lifespan
- Mean lifespan is 36% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RPO31
- Danio rerio
- polr3a
- Drosophila melanogaster
- CG17209
- Homo sapiens
- POLR3A
- Mus musculus
- Polr3a
- Rattus norvegicus
- Polr3a
- Saccharomyces cerevisiae
- RPO31
- Schizosaccharomyces pombe
- rpc1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (177491)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for rpc-1 (Caenorhabditis elegans)