- Symbol
- rle-1
- Name
- Regulation of Longevity by E3 ubiquitin ligase
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- E3 ubiquitin ligase
- Observations
- Disruption of rle-1 extended maximum lifespan by about 30%, dependent on daf-16 since disruption of daf-16 in rle-1 mutants reversed the life-extending effects. Overexpression of daf-16 in rle-1 mutants further increased lifespan. Disrupted of rle-1 also resulted in partial embryonic lethality and fewer progeny.
- % change in max lifespan
- Maximum lifespan is about 30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Danio rerio
- rc3h1a
- Danio rerio
- rc3h1b
- Danio rerio
- rc3h2
- Drosophila melanogaster
- roq
- Homo sapiens
- RC3H1
- Homo sapiens
- RC3H2
- Mus musculus
- Rc3h1
- Mus musculus
- Rc3h2
- Rattus norvegicus
- Rc3h2
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (176525)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for rle-1 (Caenorhabditis elegans)