- Symbol
- rdgA
- Name
- retinal degeneration A
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Knockdown of rdgA in flies results in increased mean lifespan by up to 44%. Similarly, rdgA mutants display increased mean lifespans of up to 53%. Simultaneous overexpression of DAGL (known lifespan extension intervention) and rdgA knockdown do not further extend lifespan of that achieved by either manipulation independently, suggesting the two interventions work through similar mechanisms.
- % change in avg or median lifespan
- Mean lifespan is up to 44% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as dgk-5
- Caenorhabditis elegans
- dgk-5
- Danio rerio
- DGKI
- Danio rerio
- dgkza
- Danio rerio
- dgkzb
- Homo sapiens
- DGKI
- Homo sapiens
- DGKZ
- Mus musculus
- Dgki
- Mus musculus
- Dgkz
- Rattus norvegicus
- Dgki
- Rattus norvegicus
- Dgkz
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (31826)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar