- Symbol
- pha-4
- Name
- defective PHArynx development
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Pharynx development
- Observations
- PHA-4 may play a role in the life-extending effects of dietary restriction. RNA interference decreased lifespan of wild-type worms, but not of daf-2 mutants or of animals with defective electron transport chains. Overexpression slightly increased longevity.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- RNAi of pha-4 in adult animals led to a slightly shortened mean lifespan (13%).
- % change in avg or median lifespan
- Average lifespan is 13% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as fkh
- GenDR gene manipulations
- This gene is present as pha-4
- CellAge
- A homolog of this gene for Homo sapiens is present as FOXA1
- Drosophila melanogaster
- fkh
- Homo sapiens
- FOXA3
- Homo sapiens
- FOXA1
- Mus musculus
- Foxa3
- Mus musculus
- Foxa1
- Rattus norvegicus
- Foxa3
- Rattus norvegicus
- Foxa1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (180357)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for pha-4 (Caenorhabditis elegans)