The pept-1 gene and its possible relation to ageing in roundworms

Gene information (ID: 482)

Symbol: pept-1
Name: OligoPeptide Transporter
Organism: Caenorhabditis elegans (AnAge)
Known functions and activities: Intestinal peptide transporter

Potential relevance to longevity and/or ageing

Observations

Gene inactivation of nhx-2 by RNAi led to a loss of fat stores in the intestine and a 40% increase in longevity while double RNAi of nhx-2 and opt-2 led to 10-20% increase in longevity

% change in avg or median lifespan

Lifespan is 40% higher.

Lifespan Effect

Increase

Genetic Manipulation

RNA interference

Longevity Category

Anti-Longevity

Primary reference

Observations

Deletion of pept1 (also called opt-2, pep-2) results in retarded development, reduced body size and extended reproductive lifespan. It also further extends (60%) the life-extension caused by daf-2 mutations.