- Symbol
- pch-2
- Name
- Putative pachytene checkpoint protein 2
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Overexpression of pch-2 in C. elegans extends lifespan and enhances worm resistance to various stressors. Conversely, RNA interference of pch-2 shortens worm lifespan. The mechanism by which pch-2 modulates worm longevity is tied to functions of the sirtuin family.
- % change in max lifespan
- Maximum lifespan is 25% higher.
- % change in avg or median lifespan
- Median lifespan is 22% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as PCH2
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as TRIP13
- Danio rerio
- trip13
- Drosophila melanogaster
- pch2
- Homo sapiens
- TRIP13
- Mus musculus
- Trip13
- Rattus norvegicus
- Trip13
- Saccharomyces cerevisiae
- PCH2
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (174313)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for pch-2 (Caenorhabditis elegans)