- Symbol
- npr-1
- Name
- NeuroPeptide Receptor family
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Worms with a loss of function mutation in npr-1 demonstrated a 15.6% increase in mean lifespan compared to control worms. Worms with an additional deletion mutation in gcy-35 demonstrated a 26.9% increase in mean lifespan compared to control worms. These extensions were dependent on gcy-33 activity.
- % change in avg or median lifespan
- Mean lifespan is 16% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Danio rerio
- si:dkey-202l22.3
- Danio rerio
- prlh2r
- Danio rerio
- prlhr2b
- Danio rerio
- prlhr2a
- Drosophila melanogaster
- sNPF-R
- Homo sapiens
- PRLHR
- Mus musculus
- Prlhr
- Rattus norvegicus
- Prlhr
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (180752)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for npr-1 (Caenorhabditis elegans)