- Symbol
- nhr-49
- Name
- Nuclear Hormone Receptor family
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Several of the RNAi candidates (dve-1; lin-40; nhr-49; ceh-20; lin-11; and nhr-77) appeared to non-discriminately shorten lifespan in all strains tested, suggesting that the corresponding transcription factors are broadly required for survival. Interestingly, four RNAi clones (ZC123.3; nhr-119; ceh-37; and aha-1) affected wild-type and isp-1;ctb-1 mutant worms' lifespan to the same extent but exerted only a moderate or no effect on daf-16 and age-1 mutant longevity.
- % change in avg or median lifespan
- Average lifespan is 56% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- RNA interference shortened lifespan and altered fatty acid composition.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Drosophila melanogaster
- Hr96
- WormBase
- Search
- Ensembl
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- Entrez Gene
- View on Entrez Gene database (172839)
- Homologues
- Search HomoloGene
- UniProt
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GenAge entry for nhr-49 (Caenorhabditis elegans)