Drosophila melanogasterGenAge entry for mth (Drosophila melanogaster)

Gene information (ID: 447)

Symbol
mth
Aliases
CG6936; Dmel\CG6936; Mth; MTH
Name
methuselah
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
G-protein coupled receptor activity

Potential relevance to longevity and/or ageing

Observations
Overexpression of Methuselah (MTH) in the insulin-producing cells of the brain, extends lifespan and enhances stress resistance in flies. Mean lifespan is increased by 12-16% in males and 14-21% in females, while maximum lifespan is increased by 9-28% in males and 25-33% in females. Paradoxically, the same experiment showed that reducing the signaling through MTH has also similar effects.
% change in max lifespan
Female maximum lifespan is up to 33% higher. Male maximum lifespan is up to 28% higher.
% change in avg or median lifespan
Female mean lifespan is up to 21% higher. Male mean lifespan is up to 16% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Reducing signaling through Methuselah (MTH), targeted to the insulin-producing cells of the brain, extends lifespan and enhances stress resistance in flies. RNA interference results in a mean extension of 27% in females and 29% in males, while maximum lifespan is extended by 37% and 50% in males and females respectively. Paradoxically, overexpressing MTH in the same cell type has also similar effects.
    % change in max lifespan
    Female maximum lifespan is 50% higher. Male maximum lifespan is 37% higher.
    % change in avg or median lifespan
    Female mean lifespan is 27% higher. Male mean lifespan is 29% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Mutants displayed approximately 35 percent increase in average lifespan and enhanced resistance to various forms of stress.
      % change in avg or median lifespan
      Lifespan is approximately 35% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Mutation
      Longevity Category
      Anti-Longevity
      Primary reference

        Homologs in other organisms

        No homologs found

        External links

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        Entrez Gene
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