- Symbol
- met-2
- Name
- Histone-lysine N-methyltransferase met-2
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Met-2 downregulation in worms shortened median lifespan by 23%. Downregulation of met-2 partially suppressed lifespan extension as a consequence of cco-1 downregulation. When met-2 was downregulated along with atfs-1 it restored the lifespan of cco-1 RNAi treated animals back to the level of the wild type.
- % change in avg or median lifespan
- Median lifespan is 23% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SET2
- Danio rerio
- setdb1b
- Danio rerio
- CABZ01090029.1
- Danio rerio
- setdb1a
- Drosophila melanogaster
- egg
- Homo sapiens
- SETDB2
- Homo sapiens
- SETDB1
- Mus musculus
- Setdb2
- Mus musculus
- Setdb1
- Rattus norvegicus
- Setdb1
- Rattus norvegicus
- Setdb2
- Saccharomyces cerevisiae
- SET2
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (176183)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for met-2 (Caenorhabditis elegans)