Caenorhabditis elegansGenAge entry for mdl-1 (Caenorhabditis elegans)

Gene information (ID: 1907)

Symbol
mdl-1
Name
MAD-Like
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Daf-2 mutants display an upregulated MDL-1. Deletion of mdl-1 shortens lifespan of wild type worm (up to 16%). Moreover, deletion in long-lived daf-2 mutants shortens lifespan to an even higher degree (up to 32%) suggesting it contributes to the effects of daf-2 on lifespan.
% change in avg or median lifespan
Mean lifespan is 16% lower.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as MXD1
    • A homolog of this gene for Homo sapiens is present as MXI1
    CellAge
    • A homolog of this gene for Homo sapiens is present as MXD4
    CellAge gene expression
    • A homolog of this gene for Homo sapiens is present as MXI1
    • A homolog of this gene for Homo sapiens is present as MXD4

    Homologs in other organisms

    Danio rerio
    mxd3
    Danio rerio
    mxi1
    Danio rerio
    mxd4
    Danio rerio
    mxd1
    Homo sapiens
    MXD1
    Homo sapiens
    MXI1
    Homo sapiens
    MXD4
    Homo sapiens
    MXD3
    Mus musculus
    Mxi1
    Mus musculus
    Mxd1
    Mus musculus
    Mxd3
    Mus musculus
    Mxd4
    Rattus norvegicus
    Mxd1
    Rattus norvegicus
    Mxi1
    Rattus norvegicus
    Mxd4

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (180942)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar