- Symbol
- loco
- Aliases
- CG17229; CG5248; dLoco; Dmel\CG5248; Loco
- Name
- locomotion defects
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Overexpression of both genomic and cDNA loco gene significantly shortened the lifespan and resulted in a reduced stress resistance and lower fat content.
- % change in avg or median lifespan
- Mean male lifespan is 20% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Overexpression
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Reduced expression of Loco, a RGS protein of Drosophila melanogaster, resulted in a longer lifespan for both hetero-deficient male and female flies, also exhibiting stronger resistance to three different stressors (starvation, oxidation, and heat) and higher manganese-containing superoxide dismutase (MnSOD) activity. In addition, this reduction in Loco expression increased fat content and diminished cAMP levels. Deletion analysis of the Loco demonstrated that its RGS domain is required for the regulation of longevity.
- % change in avg or median lifespan
- Mean lifespan is 17-20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Knockout
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Caenorhabditis elegans
- rgs-7
- Danio rerio
- rgs12b
- Danio rerio
- RGS14 (1 of many)
- Danio rerio
- rgs14a
- Danio rerio
- rgs12a
- Homo sapiens
- RGS12
- Homo sapiens
- RGS10
- Homo sapiens
- RGS14
- Mus musculus
- Rgs10
- Mus musculus
- Rgs14
- Mus musculus
- Rgs12
- Rattus norvegicus
- Rgs14
- Rattus norvegicus
- Rgs10
- Rattus norvegicus
- Rgs12
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (42672)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar