- Symbol
- itr-1
- Name
- Inositol Triphosphate Receptor
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Increased ITR-1 activity extends median and maximum lifespan (53% increase of median lifespan, 29% increase of maximum lifespan), whereas reduced ITR-1 activity shortens culture survival (i.e., -11% increase of median lifespan, -31% increase of maximum lifespan)
- % change in max lifespan
- Maximum lifespan is 29% higher.
- % change in avg or median lifespan
- Median lifespan is 53% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression or mutations
- Longevity Category
- Pro-Longevity
- Primary reference
-
- CellAge
- A homolog of this gene for Homo sapiens is present as ITPR1
- Danio rerio
- itpr1b
- Danio rerio
- itpr1a
- Drosophila melanogaster
- Itp-r83A
- Homo sapiens
- ITPR1
- Mus musculus
- Itpr1
- Rattus norvegicus
- Itpr1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (177546)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for itr-1 (Caenorhabditis elegans)