- Symbol
- hsf-1
- Name
- Heat shock transcription factor 1
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Transcription factor that is activated upon heat shock
- Observations
- Transgenic mutants overexpressing HSF-1 live longer (median lifespan ~50% higher) and are more thermotolerant.
- % change in avg or median lifespan
- Median lifespan is approximately 50% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- RNA interference suppressed normal dauer formation and life-extension due to insulin-like signalling.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- RNAi resulted in a 74% decrease in median lifespan in daf-2 background and a 45% decrease in lifespan in daf-2/daf-16 double mutant background.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as HSF1
- GenDR gene manipulations
- This gene is present as hsf-1
- CellAge
- A homolog of this gene for Homo sapiens is present as HSF1
- Danio rerio
- hsf1
- Danio rerio
- hsf4
- Drosophila melanogaster
- Hsf
- Homo sapiens
- HSF4
- Homo sapiens
- HSF1
- Mus musculus
- Hsf4
- Mus musculus
- Hsf1
- Rattus norvegicus
- Hsf1
- Rattus norvegicus
- Hsf4
- Saccharomyces cerevisiae
- HSF1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (173078)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for hsf-1 (Caenorhabditis elegans)