Caenorhabditis elegansGenAge entry for fmo-2 (Caenorhabditis elegans)

Gene information (ID: 2154)

Symbol
fmo-2
Name
Dimethylaniline monooxygenase [N-oxide-forming]
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Worms overexpressing fmo-2 demonstrated a 20% increase in mean lifespan when compared to the wild type. This pro-longevity effect was dependent on tph-1 in neurons and the serotonin receptor ser-7 in the intestine.
% change in avg or median lifespan
Mean lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenDR gene expression
    • A homolog of this gene for Mus musculus is present as Fmo3
    GenDR gene manipulations
    • This gene is present as fmo-2

    Homologs in other organisms

    Danio rerio
    si:dkey-239i20.4
    Danio rerio
    si:dkey-239i20.2
    Danio rerio
    fmo5
    Homo sapiens
    FMO2
    Homo sapiens
    FMO1
    Homo sapiens
    FMO3
    Homo sapiens
    FMO4
    Homo sapiens
    FMO5
    Mus musculus
    Fmo4
    Mus musculus
    Fmo5
    Mus musculus
    Gm4847
    Mus musculus
    Fmo9
    Mus musculus
    Gm4846
    Mus musculus
    Fmo6
    Mus musculus
    Fmo2
    Mus musculus
    Fmo3
    Mus musculus
    Fmo1
    Rattus norvegicus
    Fmo13
    Rattus norvegicus
    Fmo6
    Rattus norvegicus
    LOC685351
    Rattus norvegicus
    Fmo5
    Rattus norvegicus
    Fmo1
    Rattus norvegicus
    Fmo3
    Rattus norvegicus
    Fmo9
    Rattus norvegicus
    Fmo2
    Rattus norvegicus
    Fmo4
    Saccharomyces cerevisiae
    FMO1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (177958)
    Homologues
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    UniProt
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    Internet
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