Drosophila melanogasterGenAge entry for esc (Drosophila melanogaster)

Gene information (ID: 847)

Symbol
esc
Aliases
CG14941; dESC; Dmel\CG14941; Esc; ESC; L41867; sc
Name
extra sexcombs
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Males heterozygous for the null esc4 or the dominant negative esc9 mutation that were progeny of an out-cross to an O-R wild-type strain had median life spans that were, respectively, 47% and 60% longer than the O-R control. When derived from an out-cross to a longer-lived C-S wild-type strain, heterozygous esc9 flies had a median life span that was 43% longer than the C-S control .
% change in max lifespan
Maximum lifespan is approximately 34% higher.
% change in avg or median lifespan
Median lifespan is 59% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutations
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Caenorhabditis elegans
    mes-6
    Danio rerio
    eed
    Homo sapiens
    EED
    Mus musculus
    Eed
    Rattus norvegicus
    Eed

    External links

    FlyBase
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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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