GenAge entry for ddl-2 (Caenorhabditis elegans)
Gene information (ID: 173)
- Symbol
- ddl-2
- Name
- Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased)
- Organism
- Caenorhabditis elegans (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- RNA interference results in lifespan extension.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Inhibition of DDL-1/2 increases longevity and thermotolerance in an hsf-1-dependent manner. RNAi extends lifespan by 12%-24%.
- % change in avg or median lifespan
- Lifespan is 12-24% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
Homologs in other organisms
No homologs found
External links
- WormBase
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- Ensembl
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- Entrez Gene
- View on Entrez Gene database (190025)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar