Caenorhabditis elegansGenAge entry for daf-8 (Caenorhabditis elegans)

Gene information (ID: 170)

Symbol
daf-8
Name
abnormal DAuer Formation
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Encodes a Smad protein that represses dauer development

Potential relevance to longevity and/or ageing

Observations
Mutation in adults increased mean lifespan by 31% but it did not increase maximum lifespan.
% change in avg or median lifespan
Average lifespan is 31% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as Mad
    • A homolog of this gene for Drosophila melanogaster is present as Smox
    CellAge
    • A homolog of this gene for Homo sapiens is present as SMAD1
    • A homolog of this gene for Homo sapiens is present as SMAD2
    • A homolog of this gene for Homo sapiens is present as SMAD3
    • A homolog of this gene for Homo sapiens is present as SMAD5

    Homologs in other organisms

    Danio rerio
    smad2
    Danio rerio
    smad1
    Danio rerio
    smad5
    Danio rerio
    smad3a
    Danio rerio
    smad9
    Danio rerio
    smad3b
    Drosophila melanogaster
    Mad
    Drosophila melanogaster
    Smox
    Homo sapiens
    SMAD1
    Homo sapiens
    SMAD9
    Homo sapiens
    SMAD5
    Homo sapiens
    SMAD3
    Homo sapiens
    SMAD2
    Mus musculus
    Smad5
    Mus musculus
    Smad2
    Mus musculus
    Smad3
    Mus musculus
    Smad9
    Mus musculus
    Smad1
    Rattus norvegicus
    Smad9
    Rattus norvegicus
    LOC103691556
    Rattus norvegicus
    Smad3
    Rattus norvegicus
    Smad1
    Rattus norvegicus
    Smad2
    Rattus norvegicus
    Smad5
    Rattus norvegicus
    Smad9

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (187612)
    Homologues
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    UniProt
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    Internet
    Search Google or Search Google Scholar