- Symbol
- daf-12
- Name
- Abnormal DAuer Formation
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- A member of the steroid hormone receptor superfamily
- Observations
- Mutations in daf-2 and daf-12, but not mutations in daf-12 alone, nearly quadruple lifespan.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- daf-12(rh61rh411) is a class 3 daf-12 allele which is daf-d and results in shortened lifespan. This allele represents a putative null allele as it has two nonsense mutations affecting both the DNA binding domain (DBD) and ligand-binding domain (LBD). daf-12(rh273) is a class 6 daf-12 allele which is daf-c and results in lengthened lifespan. This allele has a R564H mutation altering a residue that in the thyroid hormone receptor makes direct contact with ligand and is believed to result in hormone insensitivity.daf-12(rh273) was much longer lived than the daf-12(rh61rh411) and showed a modest but significant increase in lifespan compared with wild-type N2 worms. The daf-12(rh273) allele results in a 38% increase in lifespan compared with daf-12(rh61rh411) and a 10% increase in lifespan compared with wild-type worms
- Lifespan Effect
- Not Recorded
- Genetic Manipulation
- Mutations
- Primary reference
-
- Drosophila melanogaster
- Hr96
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (181263)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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GenAge entry for daf-12 (Caenorhabditis elegans)