Caenorhabditis elegansGenAge entry for atx-3 (Caenorhabditis elegans)

Gene information (ID: 1758)

Symbol
atx-3
Name
Protein ATX-3
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
In contrast to single deletions, worms deficient for both cdc-48.1 (p97) and atx-3 have an extended lifespan, modulated through the insulin/IGF-1 signalling pathway.
% change in avg or median lifespan
Lifespan is up to 50% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    atxn3
    Homo sapiens
    ATXN3
    Homo sapiens
    ATXN3L
    Mus musculus
    Atxn3
    Rattus norvegicus
    Atxn3

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (180049)
    Homologues
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    UniProt
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    Internet
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