- Symbol
- Sir2
- Aliases
- BEST:LD38188; CG5216; D.mel1; Dmel\CG5216; dmSRT406; ds
- Name
- CG5216-PA
- Organism
- Drosophila melanogaster (AnAge)
- Known functions and activities
- NAD(+)-dependent histone deacetylase that silences gene expression
- Observations
- Moderate (3-fold) Sir2 overexpression in the fat body during adulthood only can promote longevity in both sexes by roughly 13%.
- % change in avg or median lifespan
- Average lifespan is 13% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Overexpression of dSir2 did not result in increased lifespan when using the appropriate transgenic controls.
- Lifespan Effect
- Noeffect
- Longevity Category
- Not Recorded
- Primary reference
-
- Observations
- Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons (10-30% median lifespan reduction) and ubiquitous silencing of the Sir2-like genes shortened lifespans. The effects were severer at 28 C than at 25 C. These results suggest that Sir2-like genes as well as Sir2 are involved in the regulation of lifespan in Drosophila.
- % change in avg or median lifespan
- Median lifespan is 10-30% higher.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Overexpression of dSir2 extends lifespan by up to 57%, whereas a decrease in dSir2 blocks the life-extending effect of caloric reduction or rpd3 mutations.
- % change in avg or median lifespan
- Lifespan is up to 57% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
- A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
- A homolog of this gene for Mus musculus is present as Sirt1
- A homolog of this gene for Saccharomyces cerevisiae is present as HST1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as SIRT1
- GenDR gene manipulations
- This gene is present as Sir2
- A homolog of this gene for Mus musculus is present as Sirt1
- A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
- A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
- A homolog of this gene for Saccharomyces cerevisiae is present as HST1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as SIRT1
- CellAge
- A homolog of this gene for Homo sapiens is present as SIRT1
- Caenorhabditis elegans
- sir-2.1
- Danio rerio
- sirt1
- Homo sapiens
- SIRT1
- Mus musculus
- Sirt1
- Rattus norvegicus
- Sirt1
- Saccharomyces cerevisiae
- SIR2
- Saccharomyces cerevisiae
- HST1
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (34708)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar