Saccharomyces cerevisiaeGenAge entry for SIR2 (Saccharomyces cerevisiae)

Gene information (ID: 606)

Symbol
SIR2
Aliases
MAR1
Name
Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
NAD(+)-dependent histone deacetylase that silences gene expression

Potential relevance to longevity and/or ageing

Observations
Overexpression extended lifespan by about 30%.
% change in avg or median lifespan
Lifespan is about 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Lack of Sir2 along with calorie restriction and/or mutations in the yeast AKT homolog, Sch9, or Ras pathways causes a dramatic chronological LS extension (6 fold).
    % change in avg or median lifespan
    Chronological lifespan is up to 6 fold higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Mean chronological lifespan increased in the a strain
      Lifespan Effect
      Increase
      Genetic Manipulation
      Deletion
      Longevity Category
      Anti-Longevity
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
        • A homolog of this gene for Drosophila melanogaster is present as Sir2
        • A homolog of this gene for Mus musculus is present as Sirt1
        • A homolog of this gene for Drosophila melanogaster is present as Sirt4
        GenAge human genes
        • A homolog of this gene for Homo sapiens is present as SIRT1
        GenDR gene manipulations
        • A homolog of this gene for Drosophila melanogaster is present as Sir2
        • A homolog of this gene for Mus musculus is present as Sirt1
        • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
        • This gene is present as SIR2
        LongevityMap
        • A homolog of this gene for Homo sapiens is present as SIRT1
        CellAge
        • A homolog of this gene for Homo sapiens is present as SIRT1

        Homologs in other organisms

        Caenorhabditis elegans
        sir-2.3
        Caenorhabditis elegans
        sir-2.1
        Caenorhabditis elegans
        sir-2.2
        Danio rerio
        sirt4
        Danio rerio
        sirt5
        Danio rerio
        sirt1
        Drosophila melanogaster
        Sir2
        Drosophila melanogaster
        Sirt4
        Homo sapiens
        SIRT5
        Homo sapiens
        SIRT1
        Homo sapiens
        SIRT4
        Mus musculus
        Sirt1
        Mus musculus
        Sirt5
        Mus musculus
        Sirt4
        Rattus norvegicus
        Sirt1
        Rattus norvegicus
        Sirt5
        Rattus norvegicus
        Sirt4

        External links

        Saccharomyces Genome Database
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (851520)
        Homologues
        Search HomoloGene
        UniProt
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        Internet
        Search Google or Search Google Scholar