- Symbol
- SIP2
- Aliases
- SPM2
- Name
- Sip2p
- Organism
- Saccharomyces cerevisiae (AnAge)
- Known functions and activities
- One of three beta subunits of the Snf1 serine/threonine protein kinase complex
- Observations
- The esa1-531 strain showed a shortened replicative lifespan when grown at a semi-permissive temperature, 30C. Importantly, in an esa1-531 strain, the lysine-to-glutamine mutants of SIP2 (sip2-3KQ and sip2-4KQ), mimicking acetylated Sip2, reversed the shortened lifespan of esa1-531.
- % change in avg or median lifespan
- Median lifespan is 60% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Acetylation mutants
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Deletion results in reduced resistance to nutrient deprivation and a shorter lifespan accompanied by signs of accelerated ageing such as accumulation of extrachromosomal rDNA.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Replicative lifespan increased by 20% in the alpha strain
- % change in avg or median lifespan
- Replicative lifespan is 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Deletion
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Mean chronological lifespan increased in the a strain
- Lifespan Effect
- Increase
- Genetic Manipulation
- Deletion
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as aakb-1
- A homolog of this gene for Caenorhabditis elegans is present as aakb-2
- Caenorhabditis elegans
- aakb-2
- Caenorhabditis elegans
- aakb-1
- Danio rerio
- PRKAB2
- Danio rerio
- prkab1b
- Danio rerio
- prkab1a
- Drosophila melanogaster
- alc
- Homo sapiens
- PRKAB2
- Homo sapiens
- PRKAB1
- Mus musculus
- Prkab2
- Mus musculus
- Prkab1
- Rattus norvegicus
- Prkab1
- Rattus norvegicus
- Prkab2
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (852664)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for SIP2 (Saccharomyces cerevisiae)