- Symbol
- Rpi
- Aliases
- CG30410; CG9872; Dmel\CG30410; rpi
- Name
- Ribose-5-phosphate isomerase
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Drosophila strain with reduced expression of ribose-5-phosphate isomerase (rpi), EP2456, exhibits increased resistance to oxidative stress and enhanced lifespan. In addition, the strain also displays higher levels of NADPH. The knockdown of rpi in neurons by double-stranded RNA interference recapitulated the lifespan extension and oxidative stress resistance in Drosophila. Whole organism silencing resulted in an increased lifespan by 8-14%, while neuronal silencing led to a 25-38% increase in mean lifespan.
- % change in avg or median lifespan
- Average lifespan is up to 38% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Caenorhabditis elegans
- rpia-1
- Danio rerio
- rpia
- Homo sapiens
- RPIA
- Mus musculus
- Rpia
- Rattus norvegicus
- Rpia
- Saccharomyces cerevisiae
- RKI1
- Schizosaccharomyces pombe
- rki1
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (246599)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
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GenAge entry for Rpi (Drosophila melanogaster)