Drosophila melanogasterGenAge entry for Pex16 (Drosophila melanogaster)

Gene information (ID: 873)

Symbol
Pex16
Aliases
CG3947; DmelPex16; Dmel\CG3947; pex16
Name
peroxin 16
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
Mutant flies lack normal peroxisomes, have an reduced adult body size (70%-85% smaller than controls) and rozy eyes, show locomotion defects and defects in the development of the nervous system. The mean longevity of the females was reduced to one-third (data not shown) and that of the males to one-fourth of the wild-type lifespan. The shortened lifespan was rescued by the simultaneous overexpression of pex16 in the fat body and differentiated neurons.
% change in avg or median lifespan
Average male lifespan is 75% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutations
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    pex16
    Homo sapiens
    PEX16
    Mus musculus
    Pex16
    Rattus norvegicus
    Pex16

    External links

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    Entrez Gene
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