- Symbol
- PHO84
- Name
- phosphate transporter PHO84
- Organism
- Saccharomyces cerevisiae (AnAge)
- Observations
- The retrograde response is activated in response to mitochondrial dysfunction and extends replicative lifespan. Rho- yeast cells have petite mitochondria and cannot support normal oxidative phosphorylation. Deletion of PHO84 in rho- cells completely abrogated replicative lifespan extension. Overexpression of PHO84 in rho+ cells increased mean replicative lifespan by 14%. In rho- cells mean replicative lifespan was increased by 37%.
- % change in avg or median lifespan
- Mean replicative lifespan is 14% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Schizosaccharomyces pombe
- SPCC2H8.02
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (854916)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
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GenAge entry for PHO84 (Saccharomyces cerevisiae)