Drosophila melanogasterGenAge entry for Nmdmc (Drosophila melanogaster)

Gene information (ID: 2098)

Symbol
Nmdmc
Name
NAD-dependent methylenetetrahydrofolate dehydrogenase
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
When Nmdmc was ubiquitously overexpressed in flies mean lifespan was increased. Specific expression of Nmdmc in the body abdominal fat led to an increase in lifespan of 23% in males and 14% in females. In addition the flies were found to be more resistant to various stresses including starvation, oxidation and heat.
% change in avg or median lifespan
Mean lifespan is 120% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as ADE3
    CellAge
    • A homolog of this gene for Homo sapiens is present as MTHFD2
    CellAge gene expression
    • A homolog of this gene for Homo sapiens is present as MTHFD2

    Homologs in other organisms

    Caenorhabditis elegans
    dao-3
    Danio rerio
    mthfd2
    Danio rerio
    mthfd2l
    Homo sapiens
    MTHFD2
    Homo sapiens
    MTHFD2L
    Mus musculus
    Mthfd2
    Mus musculus
    Mthfd2l
    Rattus norvegicus
    Mthfd2
    Rattus norvegicus
    Mthfd2l
    Saccharomyces cerevisiae
    ADE3
    Schizosaccharomyces pombe
    mtd1

    External links

    FlyBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (47895)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar