Drosophila melanogasterGenAge entry for Gclm (Drosophila melanogaster)

Gene information (ID: 294)

Symbol
Gclm
Aliases
4919; box; CG4919; Dmel\CG4919; DmGCLM; DmGCSl; GCLm; Gcs
Name
Glutamate-cysteine ligase modifier subunit
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Catalyzes the formation of glutathione

Potential relevance to longevity and/or ageing

Observations
Overexpression extended the mean lifespan by up to 24%.
% change in avg or median lifespan
Average lifespan is up to 24% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as GCLM

    Homologs in other organisms

    Caenorhabditis elegans
    E01A2.1
    Danio rerio
    gclm
    Homo sapiens
    GCLM
    Mus musculus
    Gclm
    Rattus norvegicus
    Gclm

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (248194)
    Homologues
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    UniProt
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    Internet
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