- Symbol
- Dys
- Aliases
- CG17750; CG31175; CG34157; CG7240; CG7243; CG7344; det; D
- Name
- Dystrophin
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- The loss of dys function in the heart leads to an age-dependent disruption of the myofibrillar organization within the myocardium as well as to alterations in cardiac performance. dys RNAi-mediated knockdown in the mesoderm also shortens lifespan. A moderate maximal lifespan reduction in the mesodermal dys knockdown flies (13%) was observed, but not when exclusively targeted to the heart. In contrast, half of the transheterozygous DysExel6184/Dyskx43 deficiency flies died at 29 days compared to 63 days in controls.This suggests that a moderate dys loss-of-function in all muscles, but not in just the heart, reduces the fly
- % change in max lifespan
- Maximum lifespan is 13% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference and deletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Dmd
- Danio rerio
- dmd
- Danio rerio
- drp2
- Homo sapiens
- UTRN
- Homo sapiens
- DRP2
- Homo sapiens
- DMD
- Mus musculus
- Utrn
- Mus musculus
- Dmd
- Mus musculus
- Drp2
- Rattus norvegicus
- Drp2
- Rattus norvegicus
- Utrn
- Rattus norvegicus
- Dmd
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (42327)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Dys (Drosophila melanogaster)