- Symbol
- CYR1
- Aliases
- CDC35; FIL1; HSR1; SRA4; TSM0185
- Name
- Adenylate cyclase
- Organism
- Saccharomyces cerevisiae (AnAge)
- Observations
- The CDC35-1 allele confers a 75% extension of replicative life span at 25 C
- % change in avg or median lifespan
- Replicative lifespan is 75% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, increase resistance to oxidants and extend LS by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 are required for this lifespan extension. A transposon mutagenized allele of CYR1 extends chronological life span, as measured by stationary phase survival, by 90%.
- % change in avg or median lifespan
- Chronological lifespan is 90% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutations
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Knocking out gene extends replicative lifespan by 75%.
- % change in avg or median lifespan
- Replicative lifespan is 75% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Knockout
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenDR gene manipulations
- This gene is present as CYR1
- Caenorhabditis elegans
- F43C1.1
- Danio rerio
- phlpp1
- Danio rerio
- phlpp2
- Danio rerio
- PHLPP2
- Drosophila melanogaster
- Phlpp
- Homo sapiens
- PHLPP2
- Homo sapiens
- PHLPP1
- Mus musculus
- Phlpp1
- Mus musculus
- Phlpp2
- Rattus norvegicus
- Phlpp1
- Rattus norvegicus
- Phlpp2
- Schizosaccharomyces pombe
- cyr1
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (853452)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for CYR1 (Saccharomyces cerevisiae)