GenDR Dietary Restriction Gene Manipulation: SCH9
Gene Information (Entrez Gene ID: 856612)
- Symbol
- SCH9
- Aliases
- HRM2 KOM1
- Name
- serine/threonine protein kinase SCH9
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 856612
Potential relevance to dietary restriction and ageing
- Observations
-
Transposon-mediated mutagenesis of SCH9 increases resistance to oxidants and thermal stress as well as extends chronological lifespan by 30%. SCH9 deletion increases chronological lifespan by up to threefold. [2346]. Deletion of SCH9 also increases replicative lifespan by 18% (in DBY746) [2271]. SCH9 deletion increases the replicative lifespan by 40% in the alpha strain [2504]. The extended lifespan of SCH9 deletion mutants is not further extended by low glucose DR and is independent of Sir2 [1570]. Water restriction further increases chronological lifespan of sch9Delta [2556].
- References
-
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as akt-1
- This gene is present as SCH9
- A homolog of this gene for Caenorhabditis elegans is present as sgk-1
- A homolog of this gene for Drosophila melanogaster is present as Akt1
- A homolog of this gene for Mus musculus is present as Akt1
- A homolog of this gene for Mus musculus is present as Akt2
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as AKT1
- GenAge microarray genes
- A homolog of this gene for Homo sapiens is present as SGK1
- LongevityMap
- CellAge
Homologs
- Caenorhabditis elegans
- akt-2
- Caenorhabditis elegans
- sgk-1
- Caenorhabditis elegans
- C56G2.5
- Caenorhabditis elegans
- akt-1
- Caenorhabditis elegans
- M03C11.1
- Danio rerio
- sgk2b
- Danio rerio
- akt3a
- Danio rerio
- sgk1
- Danio rerio
- akt2l
- Danio rerio
- AKT1
- Danio rerio
- sgk3
- Danio rerio
- akt2
- Danio rerio
- stk32a
- Danio rerio
- sgk2a
- Danio rerio
- akt3b
- Danio rerio
- si:ch211-195b13.1
- Drosophila melanogaster
- Akt1
- Drosophila melanogaster
- CG32944
- Homo sapiens
- AKT2
- Homo sapiens
- SGK1
- Homo sapiens
- STK32A
- Homo sapiens
- C8orf44-SGK3
- Homo sapiens
- SGK2
- Homo sapiens
- STK32C
- Homo sapiens
- AKT3
- Homo sapiens
- STK32B
- Homo sapiens
- SGK3
- Homo sapiens
- AKT1
- Mus musculus
- Stk32c
- Mus musculus
- Sgk2
- Mus musculus
- Akt3
- Mus musculus
- Sgk1
- Mus musculus
- Akt1
- Mus musculus
- Akt2
- Mus musculus
- Stk32b
- Mus musculus
- Stk32a
- Mus musculus
- Sgk3
- Rattus norvegicus
- Akt1
- Rattus norvegicus
- Sgk2
- Rattus norvegicus
- Sgk3
- Rattus norvegicus
- Akt2
- Rattus norvegicus
- Stk32b
- Rattus norvegicus
- Stk32c
- Rattus norvegicus
- Stk32a
- Rattus norvegicus
- Sgk1
- Rattus norvegicus
- Akt3
- Schizosaccharomyces pombe
- sck1
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- ID 856612
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar