Mus musculus GenDR Dietary Restriction Gene Manipulation: Foxo3

Gene Information (Entrez Gene ID: 56484)

Symbol
Foxo3
Aliases
Fkhr2 C76856 FKHRL1 Foxo3a 1110048B16Rik 2010203A17Rik
Name
forkhead box O3
Organism
Mus musculus (AnAge)
Entrez Gene ID
56484

Potential relevance to dietary restriction and ageing

Observations

The effect of Foxo3 on dietary restriction in mice was investigated. Wild type, Foxo3+/- and Foxo3-/- were subjected to a 30% dietary restriction regimen. Dietary restriction extended the lifespan of wild type mice but failed to significantly extend the lifespan of Foxo3+/- or Foxo3-/- mice, thus indicating that Foxo3 is required for lifespan extension under dietary restriction. Dietary restriction still reduced the prevalence of tumours in all mice.

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as daf-16
    • A homolog of this gene for Drosophila melanogaster is present as foxo
    • A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as FOXO3
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as foxo
    • A homolog of this gene for Caenorhabditis elegans is present as daf-16
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as FOXO3
    CellAge
    • A homolog of this gene for Homo sapiens is present as FOXO3

    Homologs

    Caenorhabditis elegans
    daf-16
    Danio rerio
    foxo3a
    Danio rerio
    foxo3b
    Drosophila melanogaster
    foxo
    Homo sapiens
    FOXO3
    Rattus norvegicus
    Foxo3
    Saccharomyces cerevisiae
    HCM1

    External links

    Mouse Genome Informatics
    Search
    Ensembl
    Search
    Entrez Gene
    ID 56484
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar