GenDR Dietary Restriction Gene Manipulation: Foxo3
Gene Information (Entrez Gene ID: 56484)
- Symbol
- Foxo3
- Aliases
- Fkhr2 C76856 FKHRL1 Foxo3a 1110048B16Rik 2010203A17Rik
- Name
- forkhead box O3
- Organism
- Mus musculus (AnAge)
- Entrez Gene ID
- 56484
Potential relevance to dietary restriction and ageing
- Observations
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The effect of Foxo3 on dietary restriction in mice was investigated. Wild type, Foxo3+/- and Foxo3-/- were subjected to a 30% dietary restriction regimen. Dietary restriction extended the lifespan of wild type mice but failed to significantly extend the lifespan of Foxo3+/- or Foxo3-/- mice, thus indicating that Foxo3 is required for lifespan extension under dietary restriction. Dietary restriction still reduced the prevalence of tumours in all mice.
- References
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In other databases
- GenAge model organism genes
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as FOXO3
- GenDR gene manipulations
- LongevityMap
- A homolog of this gene for Homo sapiens is present as FOXO3
- CellAge
- A homolog of this gene for Homo sapiens is present as FOXO3
Homologs
- Caenorhabditis elegans
- daf-16
- Danio rerio
- foxo3a
- Danio rerio
- foxo3b
- Drosophila melanogaster
- foxo
- Homo sapiens
- FOXO3
- Rattus norvegicus
- Foxo3
- Saccharomyces cerevisiae
- HCM1
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- ID 56484
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar