Mus musculus GenDR Dietary Restriction Gene Manipulation: Pck1

Gene Information (Entrez Gene ID: 18534)

Symbol
Pck1
Aliases
PEPCK Pck-1 AI265463
Name
phosphoenolpyruvate carboxykinase 1, cytosolic
Organism
Mus musculus (AnAge)
Entrez Gene ID
18534

Potential relevance to dietary restriction and ageing

Observations

GH transgenic mice (overexpressing PCK1) are shorter lived when compared to wild-type controls. When methionine is severely restricted (0.16%), GH transgenic mice still live less than wild-type controls (39%), but their lifespans is about 50% greater than on a normal diet. On a less restrictive diet (0.43% methionine) or on an enriched diet (1.3% methionine) transgenic mice live significantly less than wild type controls (55-58%)

References

    In other databases

    GenAge model organism genes
    • This gene is present as Pck1
    • A homolog of this gene for Caenorhabditis elegans is present as pck-2
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as PCK1

    Homologs

    Caenorhabditis elegans
    pck-3
    Caenorhabditis elegans
    pck-1
    Caenorhabditis elegans
    pck-2
    Danio rerio
    pck1
    Drosophila melanogaster
    CG10924
    Drosophila melanogaster
    Pepck
    Homo sapiens
    PCK1
    Rattus norvegicus
    Pck1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    ID 18534
    Homologues
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    UniProt
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    Internet
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