GenDR Dietary Restriction Gene Manipulation: Sirt1
Gene Information (Entrez Gene ID: 93759)
- Symbol
- Sirt1
- Aliases
- Sir2 Sir2a SIR2L1 AA673258 Sir2alpha
- Name
- sirtuin 1
- Organism
- Mus musculus (AnAge)
- Entrez Gene ID
- 93759
Potential relevance to dietary restriction and ageing
- Observations
-
Caloric restriction (40%) extends median lifespan of both SIRT1+/- and SIRT1+/+ mice by 51%, whereas calorically restricted SIRT1-/- mice display a similar median lifespan compared to their ad libitum counterparts. The deletion of one SIRT1 allele resulted also in a trend for decreased maximum lifespan under CR conditions.
- References
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In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
- A homolog of this gene for Drosophila melanogaster is present as Sir2
- A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
- This gene is present as Sirt1
- A homolog of this gene for Saccharomyces cerevisiae is present as HST1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as SIRT1
- GenDR gene manipulations
- LongevityMap
- A homolog of this gene for Homo sapiens is present as SIRT1
- CellAge
- A homolog of this gene for Homo sapiens is present as SIRT1
Homologs
- Caenorhabditis elegans
- sir-2.1
- Danio rerio
- sirt1
- Drosophila melanogaster
- Sir2
- Homo sapiens
- SIRT1
- Rattus norvegicus
- Sirt1
- Saccharomyces cerevisiae
- HST1
- Saccharomyces cerevisiae
- SIR2
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- ID 93759
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar