Mus musculus GenDR Dietary Restriction Gene Manipulation: Sirt1

Gene Information (Entrez Gene ID: 93759)

Symbol
Sirt1
Aliases
Sir2 Sir2a SIR2L1 AA673258 Sir2alpha
Name
sirtuin 1
Organism
Mus musculus (AnAge)
Entrez Gene ID
93759

Potential relevance to dietary restriction and ageing

Observations

Caloric restriction (40%) extends median lifespan of both SIRT1+/- and SIRT1+/+ mice by 51%, whereas calorically restricted SIRT1-/- mice display a similar median lifespan compared to their ad libitum counterparts. The deletion of one SIRT1 allele resulted also in a trend for decreased maximum lifespan under CR conditions.

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
    • A homolog of this gene for Drosophila melanogaster is present as Sir2
    • A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
    • This gene is present as Sirt1
    • A homolog of this gene for Saccharomyces cerevisiae is present as HST1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as SIRT1
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as Sir2
    • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
    • A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
    • A homolog of this gene for Saccharomyces cerevisiae is present as HST1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as SIRT1
    CellAge
    • A homolog of this gene for Homo sapiens is present as SIRT1

    Homologs

    Caenorhabditis elegans
    sir-2.1
    Danio rerio
    sirt1
    Drosophila melanogaster
    Sir2
    Homo sapiens
    SIRT1
    Rattus norvegicus
    Sirt1
    Saccharomyces cerevisiae
    HST1
    Saccharomyces cerevisiae
    SIR2

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    ID 93759
    Homologues
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    UniProt
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    Internet
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