Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: SIR2

Gene Information (Entrez Gene ID: 851520)

Symbol
SIR2
Aliases
MAR1
Name
Silent Information Regulator 2
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
851520

Potential relevance to dietary restriction and ageing

Observations

Deletion of SIR2 shortens replicative lifespan by approximately 30%. Integration of a second copy of SIR2 into the wild-type strain leads to an extension of replicative lifespan by around 35% in the W303R strain [200]. 0.5% glucose restriction fails to increase the short lifespan of sir2Delta [2260]. 0.1% glucose restriction extends replicative lifespan of sir2 mutants [2552]. 0.5, 0.1 and 0.05% glucose restriction are able to increase lifespan of sir2;fob1 double mutant to a greater extent than in wild-type. 0.05% glucose restriction further extends replicative lifespan of SIR2 overexpression mutant [2554]. Sir2 blocks extreme chronological lifespan extension as the lack of Sir2 along with DR and/or mutations in the yeast AKT homolog, Sch9, or Ras pathways causes a dramatic chronological lifespan extension (6-fold) [1564].

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
    • A homolog of this gene for Drosophila melanogaster is present as Sir2
    • This gene is present as SIR2
    • A homolog of this gene for Mus musculus is present as Sirt1
    • A homolog of this gene for Drosophila melanogaster is present as Sirt4
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as SIRT1
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as Sir2
    • A homolog of this gene for Mus musculus is present as Sirt1
    • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as SIRT1
    CellAge
    • A homolog of this gene for Homo sapiens is present as SIRT1

    Homologs

    Caenorhabditis elegans
    sir-2.3
    Caenorhabditis elegans
    sir-2.1
    Caenorhabditis elegans
    sir-2.2
    Danio rerio
    sirt4
    Danio rerio
    sirt5
    Danio rerio
    sirt1
    Drosophila melanogaster
    Sir2
    Drosophila melanogaster
    Sirt4
    Homo sapiens
    SIRT5
    Homo sapiens
    SIRT1
    Homo sapiens
    SIRT4
    Mus musculus
    Sirt1
    Mus musculus
    Sirt5
    Mus musculus
    Sirt4
    Rattus norvegicus
    Sirt1
    Rattus norvegicus
    Sirt5
    Rattus norvegicus
    Sirt4

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    ID 851520
    Homologues
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    UniProt
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    Internet
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