GenDR Dietary Restriction Gene Manipulation: age-1
Gene Information (Entrez Gene ID: 174762)
Potential relevance to dietary restriction and ageing
- Observations
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Recessive knockout mutants of age-1 have a 40-65% increase in mean lifespan and a 65-110% increase in maximum lifespan [2237] [1518]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [2441]. age-1 mutation significantly extends lifespan under ad lib, but only slightly under solid DR [2494].
- References
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In other databases
- GenAge model organism genes
- LongevityMap
- A homolog of this gene for Homo sapiens is present as PIK3CG
Homologs
- Danio rerio
- si:rp71-17i16.5
- Danio rerio
- pik3cg
- Homo sapiens
- PIK3CG
- Mus musculus
- Pik3cg
- Rattus norvegicus
- Pik3cg
- Saccharomyces cerevisiae
- VPS34
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 174762
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar