Cell Senescence Entries for SELENOH
- Cell Types
- Lung fibroblast
- Cell Lines
- MRC-5
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Observations
- SelH (C11orf31) was knocked down in lung fibroblasts (MCR-5). SelH shRNA MRC-5 cells under ambient O2 displayed a distinct profile of senescence including increased SA-beta-galactosidase expression, autofluorescence, growth inhibition, and ATM pathway activation. Such senescence phenotypes were alleviated in the presence of ATM kinase inhibitors, p53 shRNA knockdown or by maintaining the cells under 3% O2.
- Primary Reference
SELENOH Gene Information
- HGNC symbol
- SELENOH
- Aliases
- SELH; C11orf31; C17orf10
- Common name
- selenoprotein H
- Entrez Id
- 280636
- Description
- This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
SELENOH Ontologies
- Gene Ontology
-
Process: Cellular component:
Show all GO termsFunction: GO:3723; RNA binding
Homologs of SELENOH in Model Organisms
No homologs found
External links
- OMIM
- 607914
- Ensembl
- ENSG00000211450
- Entrez Gene
- 280636
- UniGene
- 655373
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SELENOH
- GeneCards
- SELENOH