Cell Senescence Entries for BLK

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    BLK Gene Information

    HGNC symbol
    BLK 
    Aliases
    MODY11 
    Common name
    BLK proto-oncogene, Src family tyrosine kinase 
    Entrez Id
    640
    Description
    This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]

    BLK Ontologies

    Gene Ontology
    Process: GO:50853; B cell receptor signaling pathway
    GO:30154; cell differentiation
    GO:16477; cell migration
    GO:45087; innate immune response
    GO:35556; intracellular signal transduction
    GO:38083; peptidyl-tyrosine autophosphorylation
    GO:32024; positive regulation of insulin secretion
    GO:42127; regulation of cell proliferation
    GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
    Cellular component: GO:31234; extrinsic component of cytoplasmic side of plasma membrane
    Function: GO:5524; ATP binding
    GO:4715; non-membrane spanning protein tyrosine kinase activity
    GO:5515; protein binding
    GO:4713; protein tyrosine kinase activity
    GO:5102; receptor binding
    Show all GO terms

    Homologs of BLK in Model Organisms

    Caenorhabditis elegans
    src-1
    Danio rerio
    blk
    Drosophila melanogaster
    Src64B
    Mus musculus
    Blk
    Rattus norvegicus
    Blk

    External links

    OMIM
    191305
    Ensembl
    ENSG00000136573
    Entrez Gene
    640
    UniGene
    146591
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    BLK
    GeneCards
    BLK