Cell Senescence Entries for ABI3
- Cell Types
- Colon cancer, Thyroid cancer
- Cell Lines
- ARO, WRO
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Observations
- Ectopic expression of ABI3 lowered transforming activity, reduced in vitro tumor growth properties, suppressed in vitro anchorage-independent growth and in vivo tumor formation, whilst also increasing cellular senescence. These responses were accompanied by upregulation of cell cycle inhibitor p21 and reduced ERK phosphorylation and E2F1 expression.
- Primary Reference
ABI3 Gene Information
- HGNC symbol
- ABI3
- Aliases
- NESH; SSH3BP3
- Common name
- ABI family member 3
- Entrez Id
- 51225
- Description
- This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
ABI3 Ontologies
- Gene Ontology
-
Process: GO:6928; movement of cell or subcellular component
GO:18108; peptidyl-tyrosine phosphorylation
GO:30334; regulation of cell migration
Cellular component: GO:5737; cytoplasm
GO:5622; intracellular
GO:30027; lamellipodium
GO:16020; membrane
Show all GO termsFunction: GO:42802; identical protein binding
GO:5515; protein binding
Homologs of ABI3 in Model Organisms
- Caenorhabditis elegans
- abi-1
- Danio rerio
- abi3a
- Danio rerio
- abi3b
- Drosophila melanogaster
- Abi
- Mus musculus
- Abi3
- Rattus norvegicus
- Abi3
External links
- OMIM
- 606363
- Ensembl
- ENSG00000108798
- Entrez Gene
- 51225
- UniGene
- 130719
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ABI3
- GeneCards
- ABI3