Cell Senescence Entries for SMAD3

Cell Types
Mammary epithelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Bryson et al. (2017) STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence. Cell Cycle 16(4)319-334 (PubMed)

SMAD3 Gene Information

HGNC symbol
SMAD3 
Aliases
HsT17436; JV15-2; MADH3 
Common name
SMAD family member 3 
Entrez Id
4088
Description
The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. It also functions as a tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, Nov 2019].

SMAD3 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:7179; transforming growth factor beta receptor signaling pathway
GO:10628; positive regulation of gene expression
GO:45944; positive regulation of transcription by RNA polymerase II
GO:90101; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:90287; regulation of cellular response to growth factor stimulus
GO:122; negative regulation of transcription by RNA polymerase II
GO:165; MAPK cascade
GO:1501; skeletal system development
GO:1649; osteoblast differentiation
GO:1657; ureteric bud development
And 78 more GO terms
Cellular component: GO:5634; nucleus
GO:5667; transcription regulator complex
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5637; nuclear inner membrane
GO:5886; plasma membrane
GO:32991; protein-containing complex
GO:785; chromatin
GO:43235; receptor complex
GO:71144; heteromeric SMAD protein complex
And 2 more GO terms
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:8270; zinc ion binding
GO:3700; DNA-binding transcription factor activity
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:3682; chromatin binding
GO:3690; double-stranded DNA binding
GO:5518; collagen binding
GO:8013; beta-catenin binding
And 30 more GO terms
Show all GO terms

Homologs of SMAD3 in Model Organisms

Caenorhabditis elegans
daf-8
Caenorhabditis elegans
sma-3
Caenorhabditis elegans
sma-2
Danio rerio
smad3b
Danio rerio
smad3a
Drosophila melanogaster
Smox
Mus musculus
Smad3
Rattus norvegicus
Smad3

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as daf-8
  • A homolog of this gene for Drosophila melanogaster is present as Smox

External links

OMIM
603109
Ensembl
ENSG00000166949
Entrez Gene
4088
UniGene
742270
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMAD3
GeneCards
SMAD3