Cell Senescence Entries for SLC25A5
- Cell Types
- Breast cancer, Osteosarcoma
- Cell Lines
- MCF-7, U2OS
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Kretova et al. (2015) TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence. Cell Signal 26(12)2903-11 (PubMed)
SLC25A5 Gene Information
- HGNC symbol
- SLC25A5
- Aliases
- 2F1; ANT2; T2; T3
- Common name
- solute carrier family 25 member 5
- Entrez Id
- 292
- Description
- This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013].
SLC25A5 Ontologies
- Gene Ontology
-
Process: GO:55085; transmembrane transport
GO:1902600; proton transmembrane transport
GO:7059; chromosome segregation
GO:8284; positive regulation of cell population proliferation
GO:140021; mitochondrial ADP transmembrane transport
GO:1990544; mitochondrial ATP transmembrane transport
GO:30218; erythrocyte differentiation
GO:1901029; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1990845; adaptive thermogenesis
GO:30183; B cell differentiation
GO:15853; adenine transport
And 5 more GO terms Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:16021; integral component of membrane
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5887; integral component of plasma membrane
GO:42645; mitochondrial nucleoid
GO:71817; MMXD complex
GO:5757; mitochondrial permeability transition pore complex
Function: GO:3723; RNA binding
GO:5515; protein binding
GO:15297; antiporter activity
GO:5471; ATP:ADP antiporter activity
GO:31625; ubiquitin protein ligase binding
GO:295; adenine nucleotide transmembrane transporter activity
GO:15078; proton transmembrane transporter activity
GO:15207; adenine transmembrane transporter activity
GO:17077; oxidative phosphorylation uncoupler activity
Homologs of SLC25A5 in Model Organisms
- Caenorhabditis elegans
- F25B4.7
- Caenorhabditis elegans
- R07E3.4
- Danio rerio
- slc25a6
- Drosophila melanogaster
- sesB
- Mus musculus
- Slc25a5
- Rattus norvegicus
- Slc25a5
- Saccharomyces cerevisiae
- AAC1
- Saccharomyces cerevisiae
- PET9
- Saccharomyces cerevisiae
- AAC3
In other databases
- GenAge model organism genes
- GenAge microarray genes
- This gene is present as SLC25A5
- CellAge gene expression
- This gene is present as SLC25A5
External links
- OMIM
- 300150
- Ensembl
- ENSG00000005022
- Entrez Gene
- 292
- UniGene
- 632282
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SLC25A5
- GeneCards
- SLC25A5