Cell Senescence Entries for PRKDC
- Cell Types
- Lung cancer
- Cell Lines
- H460
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Azad et al. (2012) Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells. Mol Cancer Res 9(12)1696-707 (PubMed)
PRKDC Gene Information
- HGNC symbol
- PRKDC
- Aliases
- DNA-PKC; DNA-PKcs; DNAPK; DNAPKc; DNPK1; HYRC; HYRC1; p350; p460; XRCC7
- Common name
- protein kinase, DNA-activated, catalytic subunit
- Entrez Id
- 5591
- Description
- This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].
PRKDC Ontologies
- Gene Ontology
-
Process: GO:16310; phosphorylation
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6303; double-strand break repair via nonhomologous end joining
GO:6310; DNA recombination
GO:2376; immune system process
GO:45087; innate immune response
GO:48511; rhythmic process
GO:6468; protein phosphorylation
GO:18105; peptidyl-serine phosphorylation
GO:1902036; regulation of hematopoietic stem cell differentiation
And 42 more GO terms Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:16020; membrane
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:5667; transcription regulator complex
GO:32991; protein-containing complex
GO:32993; protein-DNA complex
GO:32040; small-subunit processome
GO:70418; DNA-dependent protein kinase complex
And 3 more GO terms
Show all GO termsFunction: GO:5515; protein binding
GO:3723; RNA binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3677; DNA binding
GO:19904; protein domain specific binding
And 7 more GO terms
Homologs of PRKDC in Model Organisms
- Caenorhabditis elegans
- atl-1
- Danio rerio
- prkdc
- Mus musculus
- Prkdc
- Rattus norvegicus
- Prkdc
- Saccharomyces cerevisiae
- MEC1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as MEC1
- GenAge human genes
- This gene is present as PRKDC
- LongevityMap
- This gene is present as PRKDC
External links
- OMIM
- 600899
- Ensembl
- ENSG00000253729
- Entrez Gene
- 5591
- UniGene
- 491682
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PRKDC
- GeneCards
- PRKDC