Cell Senescence Entries for PPARG

Cell Types
Lung fibroblast
Cell Lines
2BS, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Gan et al. (2008) PPAR{gamma} accelerates cellular senescence by inducing p16INK4{alpha} expression in human diploid fibroblasts. J Cell Sci 121(Pt 13)2235-45 (PubMed)

PPARG Gene Information

HGNC symbol
PPARG 
Aliases
NR1C3; PPARG1; PPARG2; PPARgamma 
Common name
peroxisome proliferator activated receptor gamma 
Entrez Id
5468
Description
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008].

PPARG Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:30522; intracellular receptor signaling pathway
GO:48511; rhythmic process
GO:7154; cell communication
GO:51716; cellular response to stimulus
GO:6357; regulation of transcription by RNA polymerase II
GO:2674; negative regulation of acute inflammatory response
GO:7507; heart development
GO:8285; negative regulation of cell population proliferation
GO:9409; response to cold
GO:9410; response to xenobiotic stimulus
And 102 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:48471; perinuclear region of cytoplasm
GO:43235; receptor complex
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:4879; nuclear receptor activity
GO:976; transcription cis-regulatory region binding
GO:19903; protein phosphatase binding
GO:30331; estrogen receptor binding
GO:5515; protein binding
GO:19899; enzyme binding
And 21 more GO terms
Show all GO terms

Homologs of PPARG in Model Organisms

Caenorhabditis elegans
sex-1
Caenorhabditis elegans
nhr-38
Danio rerio
pparg
Mus musculus
Pparg
Rattus norvegicus
Pparg

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Pparg
GenAge human genes
  • This gene is present as PPARG
LongevityMap
  • This gene is present as PPARG

External links

OMIM
601487
Ensembl
ENSG00000132170
Entrez Gene
5468
UniGene
655798
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PPARG
GeneCards
PPARG