Cell Senescence Entries for PAPSS2

Cell Types
Breast cancer, Lung carcinoma, Mammary epithelial
Cell Lines
A549, HDF, MCF-10A, MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Jung et al. (2016) Heparan sulfation is essential for the prevention of cellular senescence. Cell Death Differ 23(3)417-29 (PubMed)

PAPSS2 Gene Information

HGNC symbol
PAPSS2 
Aliases
ATPSK2 
Common name
3'-phosphoadenosine 5'-phosphosulfate synthase 2 
Entrez Id
9060
Description
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

PAPSS2 Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:8152; metabolic process
GO:103; sulfate assimilation
GO:50428; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
GO:42445; hormone metabolic process
GO:7596; blood coagulation
GO:60348; bone development
Cellular component: GO:5829; cytosol
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:3824; catalytic activity
GO:5515; protein binding
GO:16779; nucleotidyltransferase activity
GO:4020; adenylylsulfate kinase activity
GO:4781; sulfate adenylyltransferase (ATP) activity
Show all GO terms

Homologs of PAPSS2 in Model Organisms

Caenorhabditis elegans
pps-1
Danio rerio
papss2a
Danio rerio
papss2b
Drosophila melanogaster
Papss
Mus musculus
Papss2
Rattus norvegicus
Papss2
Saccharomyces cerevisiae
MET14

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as MET14
CellAge gene expression
  • This gene is present as PAPSS2

External links

OMIM
603005
Ensembl
ENSG00000198682
Entrez Gene
9060
UniGene
524491
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PAPSS2
GeneCards
PAPSS2