Cell Senescence Entries for NFKB2

Cell Types
Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Iannetti et al. (2015) Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence. PLoS Genet 10(9)e1004642 (PubMed)

NFKB2 Gene Information

HGNC symbol
NFKB2 
Aliases
LYT-10; NF-kB2; p105; p49/p100; p52 
Common name
nuclear factor kappa B subunit 2 
Entrez Id
4791
Description
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].

NFKB2 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:48511; rhythmic process
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:2268; follicular dendritic cell differentiation
GO:2467; germinal center formation
GO:30198; extracellular matrix organization
GO:38061; NIK/NF-kappaB signaling
GO:48536; spleen development
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:785; chromatin
GO:5654; nucleoplasm
GO:33257; Bcl3/NF-kappaB2 complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
Show all GO terms

Homologs of NFKB2 in Model Organisms

Danio rerio
nfkb2
Drosophila melanogaster
Rel
Mus musculus
Nfkb2
Rattus norvegicus
Nfkb2

In other databases

GenAge human genes
  • This gene is present as NFKB2

External links

OMIM
164012
Ensembl
ENSG00000077150
Entrez Gene
4791
UniGene
73090
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NFKB2
GeneCards
NFKB2