Cell Senescence Entries for MYBL2
- Cell Types
- Cervical cancer, Foreskin fibroblast
- Cell Lines
- HeLa, Primary cell
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Johung et al. (2007) Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J Virol 81(5)2102-16 (PubMed)
MYBL2 Gene Information
- HGNC symbol
- MYBL2
- Aliases
- B-MYB; BMYB
- Common name
- MYB proto-oncogene like 2
- Entrez Id
- 4605
- Description
- The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].
MYBL2 Ontologies
- Gene Ontology
-
Process: GO:45944; positive regulation of transcription by RNA polymerase II
GO:6355; regulation of transcription, DNA-templated
GO:278; mitotic cell cycle
GO:43525; positive regulation of neuron apoptotic process
GO:90307; mitotic spindle assembly
GO:1990830; cellular response to leukemia inhibitory factor
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:31523; Myb complex
Show all GO termsFunction: GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
Homologs of MYBL2 in Model Organisms
- Danio rerio
- mybl2b
- Drosophila melanogaster
- Myb
- Mus musculus
- Mybl2
- Rattus norvegicus
- Mybl2
- Saccharomyces cerevisiae
- BAS1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as BAS1
- CellAge gene expression
- This gene is present as MYBL2
External links
- OMIM
- 601415
- Ensembl
- ENSG00000101057
- Entrez Gene
- 4605
- UniGene
- 179718
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- MYBL2
- GeneCards
- MYBL2